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Morgan Alexander

The University of Nottingham

The need for 3D materials in biomedicine

This talk will outline the opportunities for manmade 3D polymeric structures in medical devices, regenerative medicine and in vitro cell models for toxicology assessment. The potential of additive manufacturing methods will be illustrated both using examples from the published literature, along with unpublished data from ongoing biomaterials discovery programmes. When appropriate architectures are formed using bio-instructive polymeric materials, control of cell behaviour can be achieved that points the way to the potential of biomaterials in the next generation of medical devices.

Biography

Morgan Alexander is Professor of Biomedical Surfaces at the School of Pharmacy, University of Nottingham. He is director of the EPSRC Programme Grant in Next Generation Biomaterials Discovery and a Wellcome Trust Senior Investigator. He received his Bachelor of Science in Materials in 1988 and his PhD from the same department at The University of Sheffield in 1992.

His group develops materials for application in biological environments, characterising relationships between the surface and biological response. Understanding these relationships is critical in the development of the biomaterials of the future and is the theme running through his group's work across a variety of biomedical application areas spanning bacterial adhesion to controlling stem cell response. Much progress has been made in discovering new biomaterials using a high throughput materials screening approach.

He has contributed to books on surface chemical modification and analysis and has authored over 200 papers dealing with surfaces in high quality peer reviewed publications, including research articles in Nature Biotechnology, Nature Materials, PNAS, Nature Communications, Advanced Materials, and Biomaterials. This research is highly interdisciplinary, involving collaborators from a wide variety of fields including regenerative medicine, neuroscience, developmental biology, pharmaceutics, materials processing, plasma physics and nanofabrication, in the UK and with leading groups around the world, eg MIT and CSIRO. This work is funded by The Wellcome Trust, EPSRC, BBSRC, MRC and industry. A number of his group have gone on to take up independent research posts.

See the following videos:

Explaining high throughput materials discovery used to identify polymers with resistance to bacterial attachment - http://tinyurl.com/BactResistantMaterials

Materials discovery of materials for stem cell production - http://tinyurl.com/StemCellFactories

Recent Awards:

EPSRC Programme Grant in Next Generation Biomaterials Wellcome Trust Senior Investigator Award http://tinyurl.com/BactAdhesion

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